Membership
Special Interest Groups
Members’ Research Interests, Publications and Methods Used
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Iwona Bonney
Tufts-New England Medical Center
Department of Anesthesia
750 Washington Street NEMC #298
Boston, MA 02111
617-636-9322
617-636-9709
IBonney@tufts-nemc.org
Research Interests
Substance P - opioid interaction inpain transmission and modulation
Publications
S.E. Foran, D.B. Carr, A.W. Lipkowski, I. Maszczynska, J.E. Marchand, A. Misicka, M. Beinborn, A.S. Kopin, R.M. Kream: Substance P-opioid chimeric peptide as a novel non-tolerance forming analgesic. PNAS 97: 7621-7626, 2000.
S.E. Foran, D.B. Carr, A.W. Lipkowski, I. Maszczynska, J.E. Marchand, A. Misicka, M. Beinborn, A.S. Kopin, R.M. Kream: Inhibition of morphine tolerance development by a substance P-opioid peptide chimera. J. Pharmacol. Exp. Ther. 295: 1142-1148, 2000.
I. Maszczynska Bonney, S.E. Foran, J.E. Marchand, A.W. Lipkowski, D.B. Carr: Spinal antinociceptive effects of AA501, a novel chimeric peptide with opioid agonist and neurokinin antagonist moieties. European Journal of Pharmacology 488: 91-99, 2004.
A.W. Lipkowski, A. Misicka, D.B. Carr, G. Ronsisvalle, D. Kosson, I. Maszczynska Bonney: Neuropeptide mimetics for pain management. Pure and Applied Chemistry 76: 941-950, 2004.
P. Kosson, I. Bonney, D.B. Carr, A.W. Lipkowski: Endomorphins interact with tachykinin receptors. Peptides 26: 1667-1669, 2005.
Ted Bunin, ICSW
94 Muriel Ave
Lawrence, NY 11559
516-371-0660
516-371-6640
tbunin@hotmail.com
Victor Chang, MD
Section Hematology Oncology (111)
385 Tremont Ave
East Orange, NJ 07018
973-395-7095
973-395-7096
victor.chang@med.va.gov
Research Interests
Cancer pain
Carlton Dampier, MD
Erie Ave at Front St
Philadelphia, PA 19134-1095
215-427-5261
215-427-4281
cdampier@drexelmed.edu
Research Interests
Pain in children, Pain in sickle cell disease
Publications
Ely, E., Dampier, C., Gilday, M., O'Neal, P., Brodecki, D. Caregiver report of pain in infants and toddlers with sickle cell disease. J Pain 3:50-57, 2002.
Dampier, C., Ely, E., Brodecki, D., O'Neal, P. Home management of sickle cell pain: a daily diary study in children and adolescents J Pediatr Hematol Oncol 24:643-647, 2002.
Dampier, C., Ely, E., Brodecki, D., O'Neal, P. Characteristics of pain managed at home in children and adolescents with sickle cell disease by using daily self-reports. J Pain 3:461-470, 2002
Dampier, C., Ely, E., Eggleston, B., Brodecki, D., O'Neal, P. Physical and cognitive-behavioral activities used in the home management of sickle pain: a daily diary study in children and adolescents Pediatr Blood Cancer 43:674-678, 2004.
Dampier, C., Setty, BNY, Eggleston, B., Brodecki, D., O'Neal, P., Stuart, M. Vaso-occlusion in children with sickle cell disease: clinical characteristics and biologic correlates. J Pediatr Hematol Oncol 26:785-790, 2004.
Stuart Derbyshire, PhD
University of Birmingham
School of Psychology
Edgbaston, B15 2TT
UK
++121 414 4659
s.w.derbyshire@bham.ac.uk
Research Interests
Understanding the neural mechanisms of pain and their dysfunction in chronic functional pain
Publications
Derbyshire SWG. Genetics in Medicine: Real Promises Unreal Expectations. British Medical Journal 2001; 322: 1069.
Derbyshire SWG. Review and meta-analysis of neuroimaging data reveals differential activation from upper and lower gastrointestinal distension. American Journal of Gastroenterology 2003; 98: 12-20.
Vogt BA, Berger GR, Derbyshire SWG. Structural and functional dichotomy of human midcingulate cortex. European Journal of Neuroscience 2003; 18: 3134-3144.
Derbyshire SWG, Whalley MG, Stenger VA, Oakley DA. Cerebral activation during hypnotically induced and imagined pain. NeuroImage 2004; 23: 392-401.
Griffiths D, Derbyshire SWG, Stenger A, Logue E, Resnick N. Brain control of normal and overactive bladder. Journal of Urology, 2005; 174: 1862-1867.
Eli Eliav, DMD PhD
Research Interests
Neuropathic pain
Orofacial pain
Publications
Eli Eliav, Michael Tal and Rafael Benoliel "Experimental malignancy in the rat induces early hypersensitivity indicative of neuritis" Pain 110 (3): 727-737, 2004 (I.F: 4.829; Rank: 1/22 Anesthesiology;).
Eli Eliav, Richard H. Gracely, Oded Nahlieli and Rafael Benoliel "Quantitative Sensory Testing in Trigeminal Nerve Damage Assessment" J Orofacial Pain 18(4):339-334, 2004 (I.F: 1.340; Rank:13/49 Dent;)
Rafael Benoliel; Ravit Birenboim; Eiran Regev and Eli Eliav "Neurosensory Changes in the Infraorbital Nerve Following Zygomatic Fractures". Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 99 (6) 657-665, 2005 (I.F: 0.983; Rank: 24/49 Dent;).
E. Eliav, S. Teich, D. Nitzan, D. Abid El Raziq, O. Nahlieli, M. Tal, R.H. Gracely and R. Benoliel. "Temporomandibular arthralgia and myalgia, Can they be differentiated by trigeminal sensory assessment? ". Pain. 104(3): 481-490, 2003. (I.F: 4.829; Rank: 1/22 Anesthesiology;).
R. Benoliel, Y. Sharav, M. Tal and E.Eliav. "Management of Chronic Orofacial Pain:Today and Tomorrow". Comp Contin Ed Dent 24 (12):811-828, 2003.
Roger B Fillingim, PhD
University of Florida
1600 SW Archer Rd
PO Box 100404
Gainesville, FL 32610-0404
352-392-4539
352-392-2672
rfilling@ufl.edu
Research Interests
My research program investigates factors contributing to individual differences in the experience of pain, using laboratory pain assessment methods in both healthy volunteers and clinical populations.
One longstanding emphasis has involved sex differences in pain perception and responses to analgesics. The most recent direction of our research on sex differences investigates genetic factors that may be associated with pain responses in a sex-dependent manner.
Examining ethnic differences in pain responses, an extremely important topic given the increasing diversity of America's population.
Investigating responses to pain among African Americans, Hispanic Americans, and non-Hispanic whites in an effort to elucidate factors that may underlie ethnic group differences in pain perception.
Publications
Hastie, B.A., Riley, J.L.III, Robinson, M.E., Glover, T.L., Campbell, C.M.*, Staud, R., & Fillingim, R.B. (2005). Sex-related psychological predictors of baseline pain perception and analgesic responses to pentazocine. Biological Psychology, 69, 97-112.
Fillingim, R.B., Kaplan, L., Staud, R., Ness, T.J., Glover, T.L., Campbell, C.M.*, Mogil, J.S., & Wallace, M.R. Cluster analysis of multiple experimental pain modalities. Pain, 116, 227-237. (2005).
Fillingim, R.B., Ness, T.J., Glover, T.L., Campbell, C.M.*, Hastie, B.A., Price, D.D., & Staud, R. The a118g single nucleotide polymorphism of the ?-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans. Journal of Pain, 6, 159-167. (2005)
Campbell, C.M.*, Edwards, R.R. & Fillingim, R.B. Morphine responses and experimental pain: sex differences in side effects and cardiovascular responses but not analgesia. Journal of Pain, 6, 116-124. (2005).
Fillingim, R.B., Hastie, B.A., Ness, T.J., Glover, T.L., Campbell, C.M.*, & Staud, R. Ethnic differences in responses to multiple experimental pain stimuli. Pain, 113, 20-26. (2005).
Steven George, PT PhD
University of Florida
Health Science Center
PO Box 100154
Gainesville, FL 32610-0154
352-273-6432
352-273-6109
sgeorge@phhp.ufl.edu
http://www.phhp.ufl.edu/pt/george.shtml
Research Interests
My research interests (specific to the Genetics and Pain SIG) are investigating the interaction between pain related genetic and psychological factors in the development of post-operative chronic shoulder pain.
Publications
George SZ, Wittmer VT, Fillingim RB, Robinson ME. George SZ, Fritz JM, Bialosky JE, Donald DA. The effect of a fear-avoidance based physical therapy intervention for patients with acute low back pain: results of a randomized clinical trial. Spine. 2003;28(23):2551-2560.
George SZ, Dannecker EA, Robinson ME. Fear of pain, not pain catastrophizing, predicts acute pain intensity, but neither factor predicts tolerance or blood pressure response: an experimental investigation in pain-free individuals. Eur J Pain, in press.
Fear-avoidance beliefs and temporal summation of evoked thermal pain influence disability in patients with chronic low back pain. J Occup Rehabil, in press.
George SZ, Fritz JM, and McNeil DW. Fear-avoidance beliefs as measured by the fear-avoidance beliefs questionnaire (FABQ): change in FABQ is predictive of change in self-report of disability and pain intensity for patients with acute low back pain. Clin J Pain, in press.
George SZ and Hirsh AT. Distinguishing patient satisfaction with treatment delivery from treatment effect: a preliminary investigation of patient satisfaction with symptoms following physical therapy treatment of low back pain. Archives Phys Med Rehabil. 2005;86:1338-1344.
Silvio Glusman, PhD
Cook County Hospital
1901 W Harrison Ave
Chicago, IL 60612
312-864-3221
312-864-9276
glusil@aol.com
Research Interests
Mechanisms of neuropathic pain
Plasticity in the CNS
Publications
Is axonal sprouting necessary for phanton limb sensation? APS Mtg 2005, Boston
Marion Good, PhD FAAN
Case Western Reserve University
10900 Euclid Avenue
Cleveland, OH 44106-4904
216-368-5975
216-368-3542
mpg@case.edu
http://fpb.case.edu/Faculty/Good.shtm
Research Interests
Study of Complementary Nursing Therapies for Pain and Stress
Acute Pain
Relaxation and Music for Postoperative Pain
Stress and Immunity
Publications
Good, M., Stanton-Hicks, M., Grass, J., Anderson, G. C., Choi, C., Schoolmeesters, L. J., & Salman, A. (1999). Relief of postoperative pain with jaw relaxation, music, and their combination. PAIN, 83, 163-172.
Good, M., Anderson, G. C., Ahn, S., Cong, X., & Stanton-Hicks, M. (2005). Relaxation and music reduce pain following intestinal surgery. Research in Nursing & Health, 28, 240-251.
Good, M., Picot, B., Salem, S., Chin, C., & Picot, S. (2000). Cultural responses to music chosen for pain. Journal of Holistic Nursing, 18(3), 245-259.
Good, M., & Moore, S. (1996). Clinical practice guidelines as a new source of middle range theory: Focus on acute pain. Nursing Outlook, 44, 74-79.
Zeller, R., Good, M., Anderson, G. C., & Zeller, D. (1997). Strengthening experimental design by balancing confounding variables across eight treatment groups. Nursing Research, 46(6), 345-349.
Good, M., Wotman, S., Anderson, G. C., Ahn, S., & Cong, X. (2004). Obtaining parotid saliva specimens after major surgery. Biological Research for Nursing, 6(2), 110-116.
Martin E Hale, MD
Gold Coast Research LLC
201 NW 82nd Ave #205
Plantation, FL 33324
954-474-3331
954-474-3233
GCR4321@Bellsouth.NET
Research Interests
Clinical Trials focusing on Pain
Publications
Hale, M.; Dvergsten, C.; Gimbel, J.: Efficacy and Safety of Oxymorphone Extended Release in Chronic Low Back Pain: Results of a Randomized, Double-blind, Placebo- and Active-controlled Phase III Study. J. Pain 2005; 6 (1) 21-28
Spyker, D.; Hale, M.; Munera, C.; Wright, C.: Effectiveness and safety of buprenorphine transdermal system (BTDS) compared with hydrocodone/acetaminophen in the treatment of patients with chronic low back pain. J Pain 2002;3(2 Suppl 1):14 Abstr 653.
Spyker, D.A.; Hale, M.E.; Lederman, M.; Creanga, D.L.; Coles, C.; Reder, R.F.: Long-Term Use of Buprenorphine Transdermal System (BTDS) in Patients With Chronic Pain (abstract) J Am Geriatr Soc 2002;50(4 Suppl):S66, Abstr P162.
Barbara A Hastie
University of Florida
1600 SW Archer Road
HSC D8-37PO Box 100404
Gainesville, FL 32610-0404
352-392-9369
352- 392-2672
bhastie@dental.ufl.edu
Research Interests
Ethnic Differences in Pain and Analgesic Response as well as Gender Differences in Response to Analgesia and how those are influenced by genetic, psychosocial and environmental factors
Novel chimeric peptides
Publications
Fillingim, R.B., Ness, T.J., Glover, T.L., Campbell, C.M., Hastie, B.A., Price, D.D., and Staud, R. (2005). Morphine responses and experimental pain: sex differences in side effects and cardiovascular responses but not analgesia. Journal of Pain, 6(2), 116-124.
Fillingim, R.B., Hastie, B.A., Ness, T.J., Glover, T.L., Campbell, C.M., Staud, R. (2005). Sex-related psychological predictors of baseline pain perception and analgesic responses to Pentazocine. Biological Psychology, 69(1):97-112.
Hastie, B.A., Riley, J.L. 3rd, Fillingim, R.B., (2004). Ethnic differences in pain coping: Factor structure of the Coping Strategies Questionnaire and the Coping Strategies Questionnaire-Revised. The Journal of Pain, 5(6), 304-316.
Hastie, B.A., Riley J.R. 3rd, Fillingim, R.B. (2005). Ethnic differences and responses to pain in healthy young adults. Pain Medicine, Special Edition on Ethnic Disparities in Pain, 6(1): 80-90.
Hastie, B.A., Riley, J.L. 3rd, Robinson, M.E., Glover, T.L., Campbell, C.M., Staud, R., Fillingim, R.B. 2005). Cluster analysis of multiple experimental pain modalities. Pain, 116, 227-237.
Christine M Houlihan, MD
University of Virginia
2270 Ivy Road
Charlottesville, VA 22903
434-984-4343
434-924-2780
ch9g@virginia.edu
Research Interests
Pain in children with CP
Bone health, growth and maturation in children with CP
Publications
G. Worley, CM Houlihan, ME Herman-Giddens, L. Samson-Fang, EB Fung, VA Stallings, MR Conaway, WC Chumlea, RC Henderson, GS Liptak, ME O'Donnell, R. Calvert, PL Rosenbaum, and RD Stevenson, "Secondary Sexual Characteristics in Children with Cerebral Palsy and Moderate to Severe Motor Impairment: a Cross-Sectional Survey," Pediatrics, 110(5): 891-902, 2002.
CM Houlihan, MD; M O'Donnell, MD; M Conaway, PhD; and RD Stevenson, MD, "Bodily Pain and Health Related Quality of Life in Children with Cerebral Palsy", Developmental Medicine and Child Neurology, 46:305 - 310, 2004.
Christopher J Huser
Chicago, IL
Hwey-Fang, PhD
Chang Gung Institute of Technology
2 Chia-Pu Road West Sec
PutzChien Cherng Shin Tsuen
Chia-Yi, 613 52
05-3628800
05-3628866
hfliang@gw.cgit.edu.tw
Research Interests
Transcultural nursing in pediatric pain
Michael J Iadarola
National Institutes of Health
Building 49 Room 1A04
49 Convent DriveMSC 4410
Bethesda, MD 20892-4410
301-496-2758
301-402-0667
miadarola@dir.nidcr.nih.gov
Research Interests
My laboratory is interested in the molecular biology of nociception and pain control systems in the periphery
We explore gene regulation in these tissues in response to acute and chronic challenges.
We are also involved in generating new treatments for pain
Dorsal root ganglion and spinal cord
Publications
Karai L, Brown DC, Mannes AJ, Connelly ST, Brown J, Gandal M, Wellisch OM, Neubert JK, Olah Z and Iadarola MJ: Deletion of TRPV1-expressing primary afferent neurons for pain control. J. Clinical Investigation. 113:1344-1352, 2004.
Kim H, Neubert JN, San Miguel A, Xu K, Krishnaraju RK, Iadarola MJ, Goldman D, Dionne RA: Genetic influence on variability in human acute experimental pain sensitivity associated with gender ethnicity and psychological temperament. Pain 109: 488-496, 2004.
Kim H. Neubert JK, Rowan JS, Brahim JS Iadarola MJ, Dionne RA: Comparison of experimental and acute clinical pain responses in humans as pain phenotypes. J Pain. 5:377-84, 2004.
Takahashi S, Ohshima T, Cho A, Sreenath T, Iadarola MJ, Pant HC, Kim Y, Nairn AC, Brady RO, Greengard P, Kulkarni AB: Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling. Proc Natl Acad Sci U S A. 102:1737-42, 2005.
Brown DC, Iadarola MJ, Perkowski SZ, Hardem E, Shofer F, Karai L, Olah Z, Mannes AJ: Physiologic and antinociceptive effects of intrathecal resiniferatoxin in a canine bone cancer model. Anesthesiology 103:1052-1059, 2005.
Eufemia Jacob
6621 Fannin St
MC1-3320
Houston, TX 77030
832-824-4863
832-825-6479
exjacob@texaschildrenshospital.org
Research Interests
Pain in children with sickle cell disease pain
Symptoms and QOL in children with cancer
Individual variability in response to morphine
Publications
Jacob, E.,& Rasmussen, N.(2005). Interindividual Variations in Response to Pain and Analgesia. In Columbus, F. (Ed) Progress in Pain Research. Hauppauge, New York: Nova Science Publishers, Inc. (accepted April, 2005; in press).
Jacob, E., Miaskowski, C., Savedra, M., Beyer, J., Treadwell, M., Styles, L. (2003). Changes in intensity, location, and quality of vaso-occlusive pain in children with sickle cell disease. Pain, 102 (1-2), pp. 187-193.
Jacob, E.,&Ely, E.(2005). Sickle Cell Disease. In Von Roenn, Preodor & Paice (Eds.), Current Diagnosis &Treatment of Pain. New York: McGraw-Hill (accepted January2005; in press).
Jacob, E., Miaskowski, C., Savedra, M., Beyer, J. E., Treadwell, M.Styles, L. (2005). Are there Phases to the Acute Painful Episode in Children with Sickle Cell Disease. Journal of Pain & Symptom Management, 29(4):392-400.
Jacob, E. (2004). Neuropathic Pain in Children with Cancer. Journal of Pediatric Oncology Nursing, 21(6), 350-357
Jacob, E., Miaskowski, C., Savedra, M., Beyer, J., Treadwell, M., Styles, L. (2003). Management of pain in children with sickle cell disease. Journal of Pediatric Hematology & Oncology, 25(4), pp. 307-311.
Lee Kaplan, PhD
University of Florida
1600 SW Archer Rd
Box 100266
Gainesville, FL 32610
352-392-6453
352-392-3133
lee@ufl.edu
Research Interests
Genetic influences in pain sensitivity and analgesic effects, specifically examining various candidate genes involved in the nociceptive pathway and studying the underlying mechanisms that polymorphisms in these genes have.
Publications
Mogil, J.S., Wilson, S.G., Chesler, E.J., Rankin, A.L., Lariviere, W.R., Groce, M.K., Wallace, M.R., Kaplan, L., Grisel, J.E., and Fillingim, R.B., (2003) The Melanocortin-1 receptor gene mediates female-specific mechanisms of kappa-opioid analgesia in mice and humans. PNAS. Apr;100(8): 4867-72.
Mogil, J.S., Ritchie, J., Smith, S.B., Strasburg, K., Kaplan, L., Wallace, M.R., Romberg, R.R., Bijl, H., Sarton, E.Y., Fillingim, R.B., Dahan, A., (2005) Melanocortin-1 receptor gene variants affect pain and µ-opioid analgesia in mice and humans. J Med Genet. Jul;42:583-587
Fillingim, R.B., Kaplan, L., Staud, R., Ness, T.J., Glover, T.L., Campbell, C.M., Mogil, J.S., Wallace, M.R., (2005) The A118G single nucleotide polymorphism of the µ-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans. J Pain. Mar;6(3):159-67.
Mark K Kenny, PhD
Montefiore Medical Center
Department of Emergency Medicine
111 East 210th St
Bronx, NY 10467
718-920-7055
kenny@aecom.yu.edu
Research Interests
Basic, translational and clinical studies of acute pain management with particular emphasis on opioids, opioid receptors, respiratory depression and combination analgesics.
Publications
Bijur PE, Kenny MK, Gallagher EJ. Intravenous morphine at 0.1 mg/kg is not effective for controlling severe acute pain in the majority of patients. Ann Emerg Med. 2005 Oct;46(4):362-7.
Peter G Lacouture, MS PhD
Magidom Discovery LLC
1771 Post Rd East#228
Westport, CT 06880
USA
203-795-3732
203-891-0916
pglacouture@magidom.com
Research Interests
Using genetic information to target safe and effective analgesic treatment for patients. This targeting could be based on metabolic or receptor differences.
William R. Lariviere
University of Pittsburgh School of Medicine
Department of Anesthesiology
3550 Terrace StreetA1305 Scaife Hall
Pittsburgh, PA 15261
412-383-9904
412-647-2993
Research Interests
Behavioral genetics of variability in pain and analgesia
Genetic correlation analysis
QTL gene mapping
Genotype-phenotype associations in humans
Publications
Lariviere, W.R., Sattar, M.A., Melzack, R. (in press) Inflammation-susceptible Lewis rats demonstrate less sensitivity than resistant Fischer rats in the formalin inflammatory pain test and with repeated thermal tail flick testing. Journal of Neurophysiology.
Mogil, J.S., Wilson, S.G., Chesler, E.J., Rankin, A.L., Nemmani, K.V.S., Lariviere, W.R., Groce, M.K., Wallace, M.R., Kaplan, L., Staud, R., Ness, T.J., Glover, T.L., Stankova, M., Mayorov, A., Hruby, V.J., Grisel, J.E., Fillingim, R.B. (2003) The melanocortin-1 gene mediates female-specific mechanisms of analgesia in mice and humans. Proceedings of the National Academy of Sciences of the U.S.A. 100, 4867-4872.
Lariviere, W.R., Wilson, S.G., McLaughlin, T.M., Kokayeff, A., West, E.E., Adhikari, S.M., Wan,Y., Mogil, J.S. (2002) Heritability of nociception. III. Genetic relationships among commonly used assays of nociception and hypersensitivity. Pain 97, 75-86.
Lariviere, W.R., Chesler, E.J., Mogil, J.S. (2001) Transgenic studies of pain and analgesia: mutation or background genotype? The Journal of Pharmacology and Experimental Therapeutics 297, 467-473.
Lariviere, W.R., Melzack, R. (2000) The role of corticotropin-releasing factor in pain and analgesia. Pain 84, 1-12.
Charles E Laurito, MD
University of Illinois
1740 West Taylor Street
Chicago, IL 60612
312-996-4020
312-355-3153
sharps@uic.edu
Research Interests
Back pain
CRPS
Benefits of kyphoplasty following vertebral body fracture
Publications
Lu Y, Park T, Rice F, Laurito CE: The Absence of Substance P and CGRP in the Dorsal Root Ganglia of Naked Mole Rats Selectively Alters the Animal's Response to Noxious Stimuli. Proceedings of the 10th World Congress on Pain, 2004, p. 235-243.
Yeomans DC, Jones T, Laurito CE, Lu Y, Wilson SP: Reversal on ongoing thermal hyperalgesia in mice by a recombinant herpesvirus that encodes human preproenkephalin. Molecular Therapy Vol. 9, no. 1, Jan 2004.
Lu Y, Pappas GD, Laurito CE, Jing R, Yeomans DC: Porcine chromaffin cells: isolation, culture, and transplant for antinociceptive effects. Experimental Neurol. 187: 213-218, 2004.
Todorov L, Laurito CE, Schwartz DE: Postural headache in the presence of cerebral venous sinus thrombosis. Anesth Analg. 2005 Nov;101(5):1499-500.
Yeomans DC, Lu Y, Laurito CE, Votta-Velis EG., Wilson SP, and Pappas GD: Recombinant Herpes Vector-Mediated Analgesia in a Primate Model of Hyperalgesia. Molec. Ther., in press.
Alan R Light, BA PhD
University of Utah
Dept. of Anesthesiology 3C444 SOM
30 N 1900 E
Salt Lake City, UT 84132
801-587-4826
alan.light@hsc.utah.edu
Research Interests
Neurobiology of Nociception: We are currently investigating the role of spinal cord glia in the long-term enhancement of pain, and the role of proton sensing receptors in fatigue and myalgia
Publications
Kruger L, Kavookjian AM, Kumazawa T, Light AR, Mizumura K. Nociceptor structural specialization in canine and rodent testicular "free" nerve endings J Comp Neurol. 463:197-211, (2003) Light, A.R. and Perl, E.R. (2003)
Kruger L, Kavookjian AM, Kumazawa T, Light AR, Mizumura K. Nociceptor structural specialization in canine and rodent testicular "free" nerve endings J Comp Neurol. 463:197-211, (2003)
Unmyelinated afferent fibers are not only for pain anymore. J. Comp. Neurol. 461: 137-139. Wu Y, Willcockson HH, Maixner W, Light AR Suramin inhibits spinal cord microglia activation and long-term hyperalgesia induced by formalin injection. J Pain. 5:48-55, (2004)Light, A.R. (2004)
"Nocifensor" system re-revisited. Focus on Two types of C nociceptor in human skin and their behavior in areas of capaicin-induced secondary hyperalgesia". J Neurophysiol. 91:2401-3. Light, AR, Wu, Y, Hughen, RW, Guthrie, PB. (in press) Purinergic receptors activating rapid intracellular Ca2+ increases in microglia. Neuron Glia Biology
John D Loeser, MD
University of Washington
Department of Neurological Surgery
U of W Box 35670
Seattle, WA 98195
206-543-3570
206-543-8315
jdloeser@u.washington.edu
Research Interests
Neuropathic pain states
Joyce Lowinson, MD
Rockefeller University
111 East 56 Street
New York, NY 10022
212-753-8600
212-754-5683
lowinsj@mail.rockefeller.edu
Research Interests
Research and treatment of chronic non malignant pain
Joanne R Mathiasen, PhD
Cephalon Inc
CNS Biology
145 Brandywine Pkwy
West Chester, PA 19380
610-738-6634
jmathias@cephalon.com
Research Interests
Chronic/neuropathic pain
Basic and clincal research
Publications
Mathiasen, J.R. and Vaught, J.L. 1987 [D-Pen2, L-Pen5]enkephalin induced analgesia in the jimpy mouse: in vivo evidence for delta-receptor mediated analgesia. Eur. J. Pharmacol., 136:405-407
J.R. and Raffa, R.B. 1988 Examination of the involvement of supraspinal and spinal mu- and delta-opioid receptors in analgesia using the mu receptor-deficient CXBK mouse. J. Pharmacol. Exp. Ther. 245(1):13-16 Mathiasen, J.R., Arbogast
Vaught, J.L., Mathiasen, , L.A. and Voogt, J.L. 1992 Central serotonin decreases tyrosine hydroxylase activity and mRNA in the hypothalamus of female rats: possible mechanism for prolactin release. J. Neuroendocrinol.
4(5):631-639 Mathiasen, J.R., Maciejewski-Lenoir, D., Bloom, F.E., and Sladek, C.D. 1996 Increased vasopressin (VP) secretion from hypothalamic cultures following exogenous VP mRNA administration. Exp. Neurol. 141:165-172.
Mathiasen, J.R., McKenna, B.A.W., Saporito, M.S., Ghadge, G.D., Roos, R.P., Holskin, B.P., Wu, Z-L., Trusko, S.P., Connors, T.C., Maroney, A.C., Bozyczko-Coyne, D. 2004 Inhibition of Mixed Lineage Kinase (MLK) 3 prevents MPP+-induced neurotoxicity in SH-SY5Y cells. Br. Research 1003:86-97.
Christine Miaskowski, RN PhD FAAN
University of California
Department of Physiological Nursing
2 Koret WayPO Box 0610
San Francisco, CA 94143-0610
415-476-9407
415-476-8899
chris.miaskowski@nursing.ucsf.edu
Research Interests
Pain and symptom management in patients with cancer
Jeffrey S Mogil, PhD
McGill University
Dept of Psychology and Centre for Research on Pain
1205 Dr. Penfield Ave
Montreal, QC h5A 1B1
CN
514-398-4896
514-398-6085
jeffrey.mogil@mcgill.ca
paingeneticslab.ca
Research Interests
Mouse QTL mapping
Transgenic models
Mouse-to-human genetic translation
Publications
Mogil, J.S. et al. Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene. Proc. Natl. Acad. Sci., U.S.A., 102:12938-12943, 2005.
The Genetics of Pain (J.S. Mogil, Ed.), Progress in Pain Research and Management, Vol. 28, IASP Press, Seattle, 2004, 349 pp. Mogil, J.S. et al. The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans.
Proc. Natl. Acad. Sci. USA, 100:4867-4872, 2003. Mogil, J.S. The genetic mediation of individual differences in sensitivity to pain and its inhibition
Proc. Natl. Acad. Sci. USA, 96: 7744-7751, 1999. Mogil, J.S. and Grisel, J.E. Transgenic studies of pain. Pain, 77: 107-128, 1998.
Carlo Pancaro, MD
75 Francis Street
Boston, MA 02115
Research Interests
Differences in pain between genders
Chronic pain
Labor pain
Publications
Sevoflurane analgesia in obstetrics: a pilot study. Int J Obstet Anesth. 2003 Apr;12(2):79-82.
Clonidine-induced neuronal activation in the spinal cord is altered after peripheral nerve injury. Anesthesiology. 2003 Mar;98(3):748-53.
Peripheral nerve injury alters the alpha2 adrenoceptor subtype activated by clonidine for analgesia. Anesthesiology. 2002 Sep;97(3):636-41.
Obstetric analgesia: back to the future? J Matern Fetal Neonatal Med. 2003 Jul;14(1):6-7.
Jay Portnow, MD PhD
377 Belmont St
Brockton, MA 02301
USA
508-580-5380
508-580-1875
jportnow@hotmail.com
Rajan Radhakrishnan, Bpharm PhD
Western University of Health Sciences
College of Pharmacy
309 E Second St
Pomona, CA 91766
909-469-5544
rradhakrishnan@westernu.edu
Research Interests
Pain neurobiology: specifically chronic pain and spinal, supraspinal involvements
Publications
Radhakrishnan R., Sluka KA. Deep tissue afferents, but not cutaneous afferents, mediate TENS-induced antihyperalgesia. J Pain (in press).
Radhakrishnan R., Sluka KA. Acetazolamide, a carbonic anhydrase inhibitor, reverses inflammation-induced thermal hyperalgesia in rats. J Pharmacol Exp Ther. 2005, 313:921-927.
Radhakrishnan R, Sluka KA. Spinal muscarinic receptors are activated during low or high frequency TENS-induced antihyperalgesia in rats. Neuropharmacology. 2003,45:1111-1119.
Radhakrishnan R, King EW, Dickman J, Richtsmeier C, Schardt N, Spurgin M, Sluka KA. 5-HT2 and 5-HT3 receptors mediate low, but not high, frequency TENS- induced antihyperalgesia in rats. Pain, 2003,105:205-213.
Radhakrishnan R, Moore SA, Sluka KA. Unilateral carrageenan injection into muscle or joint induces chronic bilateral hyperalgesia in rats. Pain, 2003, 104:567-577.
Cielito C. Reyes-Gibby, DrPH
U.T. M. D. Anderson Cancer Center
Department of Epidemiology
1155 Pressler Street - Unit 1340Room CPB4.3279
Houston, TX 77030
713-792-1816
713-792-0807
Research Interests
Genetic, clinical, and classical epidemiology methods of analyses
Gene-environment and gene-gene interaction
Haploytpe effects and haplotype interaction
Pathway-based approach to human association studies
Sandra L Siedlecki, RN PhD
9500 Euclid Ave P32
Cleveland, OH 44195
216-444-3896
216-636-0269
siedles@ccf.org
Research Interests
ANS and HPA patterns associated with chronic pain and use of complementary therapies
Scott Strassels, PharmD PhD BCPS
University of Texas at Austin
1 University Station
A1910
Austin, TX 78712
512-471-5657
512-471-3657
scotts1@mail.utexas.edu
Research Interests
Influence of pharmacogenetics on pain and analgesia
Publications
Strassels SA, McNicol E, Suleman R. Postoperative pain management: A practical review, part 2. American Journal of Health-System Pharmacists 2005;62:2019-2025.
Strassels SA, McNicol E, Suleman R. Postoperative pain management: A practical review, part 1. American Journal of Health-System Pharmacists 2005;62 1904-1916.
McNicol E, Strassels SA, Goudas L, Lau J, Carr DB. NSAIDS or paracetamol, alone or combined with opioids, for cancer pain. The Cochrane Database of Systematic Reviews 2005, Issue 2. Art. No.: CD005180. DOI: 10.1002/14651858.CD005180. This version first published online: 20 April 2005 in Issue 2, 2005.
Strassels SA, McNicol E, Wagner AK, Rogers WH, Gouveia WA, Carr DB. Persistent postoperative pain, health-related quality of life, and functioning one month after hospital discharge. Acute Pain 2004;6(3-4):95-104.
McNicol E, Strassels S, Goudas L, Lau J, Carr D. Nonsteroidal anti-inflammatory drugs, alone or combined with opioids, for cancer pain: a systematic review. Journal of Clinical Oncology 2004;22:1975-92
Camilla I Svensson, PhD
University of California San Diego
9500 Gilman Drive
La Jolla, CA 92093
619-543-6197
619-543-6070
csvensson@ucsd.edu
Research Interests
The role of spinal non-neruonal cells in inflammatory pain
Publications
Svensson CI, Marsala M, Westerlund A, Calcutt NA, Campana WM, Freshwater JD, Catalano R, Feng Y, Protter AA, Scott B, Yaksh TL. Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing. Journal of Neurochemistry. 2003 Sep;86(6):1534-44
Svensson CI, Fitzsimmons B, Azizi. S, Powell HC, Hua XY, Yaksh TL. Spinal p38? isoform mediates tissue injury-induced hyperalgesia and spinal sensitization. Journal of Neurochemistry. 2005 Mar;92(6):1508-20.
Lucas KK, Svensson CI, Hua XY, Yaksh TL, Dennis EA. Phospholipase A2 in Spinal Inflammatory Hyperalgesia: Role of Group IV cPLA2 and Group VI iPLA2. British Journal of Pharmacology. 2005 Apr;144(7):940-52 (LKK and CIS shared first authorship)
Svensson CI, Schafers M, Jones, TL, Powell CH, Sorkin LS. Spinal blockade of TNF blocks SNL-induced increase in spinal p38. Neuroscience Letters. 2005 May 13;379(3):209-13
Svensson CI, Killermann Lucas K, Hua XY, Dennis EA, Yaksh TL. Spinal Phospholipase A2 in Inflammatory Hyperalgesia: Role of the small, secreted sPLA2's. Neuroscience. 2005;133(2):543-53.
Svensson CI, Hua XY, Powell HC, Potter AA, Lai J, Porreca F, Yaksh TL. Spinal PGE2 release evoked by intrathecal dynorphin is dependent on microglial p38 MAPK. (Accepted with minor revision, Neuropeptides. 2005 Oct;39(5):485-94
Michael Tal, DMD MS Prof
Hebrew University of Jerusalem
Medical School
Anatomy Department
972-26758456
972-26757451
talm@cc.huji.ac.il
Research Interests
Neuropathic pain mechanisms and genetics
Publications
Tal. M. PI, Sharav,Y. PI (2005) Jaw clenching modulates sensory perception in- high but not low- hypnotizable subjects. J Orofacial Pain 19:76-81.
Gabay. E, S and Tal. M. PI: (2004) Pain behavior and nerve electrophysiology in the CCI model of neuropathic pain. Pain 110(1-2):354-360).
Eliav, E. . S, Tal, M PI , and R., Benoliel, PI.: (2004) Experimental malignancy in the rat induces early hypersensitivity indicative of neuritis. Pain 110(3):727-37.
Cherkas,P.S.,s Huang, T.Y.,s Pannicke, T.,c Tal, M. ,c Reichenbach A.,c Hanani, M PI.:(2004) . The effects of axotomy on neurons and satellite glial cells in mouse trigeminal ganglion. Pain 110(1-2):290-8.
Wolf, G.*,Gabay, E.*,Tal, M.,Yirmiya, R., Shavit, Y. Impairment of Interleukin-1 (IL-1) Signaling Attenuates Neuropathic Pain and Spontaneous Ectopic Neuronal Activity Following Nerve Injury. In Press Pain.
Sharav, Y. and Tal, M.: Focused hypnotic analgesia: local and remote effects. Revised submitted to Pain.
Brad Taylor
Research Interests
Pain and analgesia
Jon-Kar Zubieta, MD PhD
University of Michigan
Molecular and Behavioral Neuroscience Institute
205 Zina Pitcher Place
Ann Arbor, MI
734-763-6843
734-647-4130
zubieta@umich.edu
Research Interests
Functional and neurochemical mechanisms underlying pain regulation in humans, as measured with imaging techniques (PET, fMRI). Genetic factors and environmental influences.
Placebos, active drug treatment effects on pain regulatory mechanisms.
Publications
Zubieta JK, Smith YR, Bueller JA, Xu Y, Kilbourn MR, Meyer CR, Koeppe RA, Stohler CS: Regional mu opioid receptor regulation of sensory and affective dimensions of pain. Science 293:311-315, 2001
Zubieta JK, Smith YR, Bueller JA, Xu Y, Woike TM, Kilbourn MR, Meyer CR, Koeppe RA, Stohler CS: µ-Opioid receptor-mediated antinociceptive responses differ in men and women. J Neurosci 22:5100-5107, 2002
Zubieta JK, Heitzeg MM, Smith YR, Bueller JA, Xu K, Xu Y, Koeppe KA, Stohler CS, Goldman D: COMT val158met genotype affects mu opioid neurotransmitter responses to a pain stressor. Science 299:1240-1243, 2003
Zubieta JK, Bueller JA, Jackson LR, Scott DJ, Xu Y, Koeppe RA, Stohler CS. Placebo effects mediated by endogenous opioid neurotransmission and µ-opioid receptors. J Neurosci 25:7754-7762, 2005